Source: Kronos Longevity Research Institute website (www.KronosInstitute.org) Sep 9, 2010

Aging Concepts

Symptoms of Aging

  • Diminished Sensory Acuity
  • Wrinkling Drooping Skin
  • Graying Hair / Baldness
  • Decreased Muscle Mass & Strength
  • Increased Body Fat
  • Reduced Energy & Stamina
  • Diminished Mobility & Flexibility
  • Insomnia
  • Stiff & Painful Joints

Theories of Aging

  • Genetic
    • Aging is "programmed" into the genes
    • Certain genes are "timekeepers" for the aging process
  • Wear and Tear
    • Factors in the environment cause cumulative damage to cells
    • Mechanisms to resist and repair damage are critical

Changes in Body Composition

  • Loss of lean body (muscle) mass
  • Decreased strength
  • Decreased fitness and loss of functional capacity
  • Increase in total fat mass (percent body fat)
  • Insulin resistance (type 2 diabetes)
  • Increased LDL cholesterol, triglycerides, and fatty acids
  • Decreased bone density (negative calcium balance)

Metabolic / Physiologic Function

  • Decreased protein synthesis
  • Slower healing
  • Reduced immune system function
  • Altered hormone balance

Diseases of Aging

  • Cardiovascular Disease
  • Hypertension
  • Stroke
  • Cancer
  • Arthritis
  • Type II Diabetes
  • Osteoporosis
  • Senile Dementia
  • Alzheimer
  • Parkinson
  • Frailty
  • Sarcopenia (loss of muscle and strength)
  • Immune deficiency
Kronos Longevity Research Institute
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