KLRI Home
> Research
> Current
> Publications
Florence S. Mahoney Seminar Series
Formerly known as Progress in Longevity Medicine Seminar Series (PLMSS)
Statin Non-Responders and Residual Risk:
Harvey S. Hecht, MD, FACC
Lenox Hill Heart & Vascular Institute
Albert Einstein College of Medicine
New York, NY
Abstract: Despite the significant event reduction, the unacceptably high event rate in the treated groups in statin monotherapy trials, ranging from a low of 5.5% in primary prevention to a high of 22.4% in secondary prevention has focused attention on reducing this "residual risk". Most of the ongoing efforts are directed towards non LDL-C targets of therapy or to achieve the elusive ideal LDL-C level, but results will not be available until the completion of trials already in progress or still in the planning stage. Notwithstanding treatment of non-LDL-C factors, the alternative of treating everyone to an "ideal" LDL-C level and hoping for the best has proved unsuccessful. The lack of success may be an inevitable consequence of the "ideal LDL-C" concept, for which there is neither data driven nor logical support. Biologic variability would argue against there being an "ideal" or even normal level of any risk factor that can be applied to everyone. An attractive alternative to monitoring the response of risk factors to treatment, e.g., change in LDL on statin therapy, would be to monitor the treatment effects on the most important components of the disease process: 1) subclinical anatomic disease in the target organs, i.e., the cardiovascular circulation, and 2) functional assessment of disease activity measured by endothelial function and inflammatory markers.
Objectives
Dr. Hecht has also served as Director of Electron Beam Tomography and Preventive Cardiology at the Heart & Vascular Institute in Morristown, NJ, the Princeton Longevity Center, and Beth Israel Medical Center, NY. Dr. Hecht has been an Instructor in Medicine at Harvard Medical School, Assistant Professor at UCLA, and Associate Professor at the University of Southern California and University of California, San Francisco. He also served as Director of Electron Beam Tomography, Cardiac Imaging and Preventive Cardiology at the Arizona Heart Institute and was Chairman of the Department of Medicine at the Arizona Heart Hospital.
Dr. Hecht has pioneered the development of noninvasive tomographic coronary angiography. He is the leader in the incorporation of coronary CTA into the catheterization laboratory and the world of coronary intervention. Dr. Hecht has been credited with the creation of the new field of "interventional lipidology", integrating early detection by imaging with an aggressive approach to the drug treatment of cholesterol disorders.
Dr. Hecht received his BA at Columbia College and his MD at the Albert Einstein College of Medicine. He completed his internship and residency in Internal Medicine at the Albert Einstein College of Medicine and Mount Sinai Hospital. He also did a fellowship in Cardiology at Beth Israel Hospital, Harvard Medical School. Dr. Hecht is board-certified in Internal Medicine and Cardiovascular Diseases, and is a Fellow of the American College of Cardiology.
To RSVP or for additional information, please contact Stephanie Tusalem at (602) 778-7492 or via email at stephanie.tusalem@kronosinstitute.org.
"This program is accredited by the Accreditation Council for Continuing Medical Education and designates this educational activity for 1 hour in Category 1 credit toward the AMA Physician's Recognition award. Each physician should claim only those hours of credit that he/she actually spent in the educational activity."
"The University of Arizona College of Medicine at the Arizona Health Sciences Center designates this educational activity for a maximum of 1.0 AMA/PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity."
CME Credit is available through University of Arizona, College of Medicine to attendees
Sponsored by the University of Arizona College of Medicine at the Arizona Health Sciences Center
Formerly known as Progress in Longevity Medicine Seminar Series (PLMSS)
Statin Non-Responders and Residual Risk:
Early Detection and Management of Patients with Progressive Atherosclerosis Despite Lowering LDL to Optimum Levels
Harvey S. Hecht, MD, FACCLenox Hill Heart & Vascular Institute
Albert Einstein College of Medicine
New York, NY
| Date/Time: | Friday, April 17, 2009; 5:30 pm (dinner included) |
| New Location: | Doubletree Guest Suites, 320 North 44th St., Phoenix, AZ 85008 |
| Cost: | No cost to attend |
Abstract: Despite the significant event reduction, the unacceptably high event rate in the treated groups in statin monotherapy trials, ranging from a low of 5.5% in primary prevention to a high of 22.4% in secondary prevention has focused attention on reducing this "residual risk". Most of the ongoing efforts are directed towards non LDL-C targets of therapy or to achieve the elusive ideal LDL-C level, but results will not be available until the completion of trials already in progress or still in the planning stage. Notwithstanding treatment of non-LDL-C factors, the alternative of treating everyone to an "ideal" LDL-C level and hoping for the best has proved unsuccessful. The lack of success may be an inevitable consequence of the "ideal LDL-C" concept, for which there is neither data driven nor logical support. Biologic variability would argue against there being an "ideal" or even normal level of any risk factor that can be applied to everyone. An attractive alternative to monitoring the response of risk factors to treatment, e.g., change in LDL on statin therapy, would be to monitor the treatment effects on the most important components of the disease process: 1) subclinical anatomic disease in the target organs, i.e., the cardiovascular circulation, and 2) functional assessment of disease activity measured by endothelial function and inflammatory markers.
Objectives
- Understand noninvasive techniques for detecting subclinical atherosclerosis
- Understand evaluation of disease activity
- Integrate 1 and 2 to evaluate residual risk
Dr. Hecht has also served as Director of Electron Beam Tomography and Preventive Cardiology at the Heart & Vascular Institute in Morristown, NJ, the Princeton Longevity Center, and Beth Israel Medical Center, NY. Dr. Hecht has been an Instructor in Medicine at Harvard Medical School, Assistant Professor at UCLA, and Associate Professor at the University of Southern California and University of California, San Francisco. He also served as Director of Electron Beam Tomography, Cardiac Imaging and Preventive Cardiology at the Arizona Heart Institute and was Chairman of the Department of Medicine at the Arizona Heart Hospital.
Dr. Hecht has pioneered the development of noninvasive tomographic coronary angiography. He is the leader in the incorporation of coronary CTA into the catheterization laboratory and the world of coronary intervention. Dr. Hecht has been credited with the creation of the new field of "interventional lipidology", integrating early detection by imaging with an aggressive approach to the drug treatment of cholesterol disorders.
Dr. Hecht received his BA at Columbia College and his MD at the Albert Einstein College of Medicine. He completed his internship and residency in Internal Medicine at the Albert Einstein College of Medicine and Mount Sinai Hospital. He also did a fellowship in Cardiology at Beth Israel Hospital, Harvard Medical School. Dr. Hecht is board-certified in Internal Medicine and Cardiovascular Diseases, and is a Fellow of the American College of Cardiology.
"The University of Arizona College of Medicine at the Arizona Health Sciences Center designates this educational activity for a maximum of 1.0 AMA/PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity."
Sponsored by the University of Arizona College of Medicine at the Arizona Health Sciences Center
Phone: (866) 840-1117 - Fax: (602) 778-7490 - Email: info@kronosinstitute.org
Copyright 2010 KLRI. All rights reserved. Terms of Usage - Privacy Policy