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Journal Papers By Topic

Hormones and Aging

Bosch, PR, Traustadóttir T, Matt KS. (2002). Neuroendocrine responses to stress: Linkages to disease predisposition. Stress, 5:96.

Rodriguez A, Muller DC, Metter EJ, Maggio M, Harman SM, Blackman MR, Andres R (2007). Aging, androgens, and the metabolic syndrome in a longitudinal study of aging. J Clin Endocrinol Metab 92:3568-3572

Münzer T, Rosen CJ, Harman SM, Pabst KM, St Clair C, Sorkin JD, Blackman MR. Effects of GH and/or sex steroids on circulating IGF-I and IGFBPs in healthy, aged women and men. Am J Physiol Endocrinol Metab 2006 May;290(5):E1006-13.

Hougaku H, Fleg JL, Najjar SS, Lakatta EG, Harman SM, Blackman MR, Metter EJ. Relationship between androgenic hormones and arterial stiffness, based on longitudinal hormone measurements. Am J Physiol Metab 2006 Feb;290(2):E234-42.

Harman SM and Blackman MR. The effects of growth hormone and sex steroid on lean body mass, fat mass, muscle strength, cardiovascular endurance and adverse events in healthy elderly women and men. Horm Res. 2003;60(Suppl 1):121-4.

Blackman MR, Sorkin JD, Münzer T, Bellantoni MF, Busby-Whitehead J, Stevens TE, Jayme J, O'Connor KG, Christmas C, Tobin JD, Stewart KJ, Cottrell E, St. Clair C, Pabst KM, and Harman SM. Effects of growth hormone and sex steroid administration in healthy aged women and men. JAMA 2002 Nov 13;288(18):2282-92.

Münzer T, Harman SM, Hees P, Shapiro E, Christmas C, Bellantoni MF, Stevens T, O'Connor KG, Pabst KM, St.Clair C, Sorkin JD, and Blackman MR. Effects of GH and/or sex steroid administration on abdominal subcutaneous and visceral fat in healthy aged women and men. Metab 2001 Aug;86(8):3604-10 J Clin Endocrinol.

Christmas C, O'Connor KG, Harman SM, Tobin JD, Münzer T, Bellantoni MF, St. Clair C, Pabst KM, Sorkin JD, and Blackman MR. Growth hormone and sex steroid effects on bone metabolism and bone mineral density in healthy aged women and men. J Gerontol 2002; 57A: M12-8.

Gusenoff J, Harman SM, Veldhuis JD, Jayme JJ, St. Clair C, Münzer T, Christmas C, O'Connor KG, Stevens TE, Bellantoni MF, Pabst K, and Blackman MR. Cortisol and GH secretory dynamics, and their interrelationships, in healthy aged women and men. Metab 2001 Apr;280(4):E616-25 Am J Physiol Endocrinol.

Hormones (Male)

Muniyappa R, Sorkin JD, Veldhuis JD, Harman SM, Munzer T, Bhasin S, Blackman MR (2007). Long-term testosterone supplementation augments overnight growth hormone secretion in healthy older men. Am J Physiol Endocrinol Metab 293:E769-775.

Muniyappa R, Wong KA, Baldwin HL, Sorkin JD, Johnson ML, Bhasin S, Harman SM, Blackman MR. Dehydroepiandrosterone secretion in healthy older men and women: effects of testosterone and growth hormone administration in older men. J Clin Endocrinol Metab 2006 Nov;91(11):4445-52.

Harman SM. Testosterone in older men after the Institute of Medicine Report: where do we go from here? Climacteric 2005 Jun;8(2):124-35.

Harman SM and Blackman MR. Use of growth hormone for prevention or treatment of effects of aging. J Gerontol A Biol Sci Med Sci 2004 Jul;59(7):652-8.

Harman SM, Metter EJ, Tobin JD, Pearson J, and Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. Metab 2001 Feb;86(2):724-31 J Clin Endocrinol.

Marcell TJ, Harman SM, Urban RJ, Metz DD, Rodgers BD, and Blackman MR. Comparison of GH, IGF-I, and testosterone with mRNA of receptors and myostatin in skeletal muscle in older men. Am J Physiol (Endocrinol Metab) 2001; 281:E1159-64.

O'Connor KG, Tobin JD, Harman SM, Plato CC, Roy TA, Sherman SS, and Blackman MR. Serum levels of insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-3, and prostate-specific antigen as predictors of clinical prostate cancer. Metab 2000 Nov;85(11):4258-65 J Clin Endocrinol.

Moffatt SD, Zonderman AB, Harman SM, Blackman MR, and Resnick SM. The relationship between longitudinal declines in dehydroepiandrosterone sulfate concentrations and cognitive performance in older men. Arch Intern Med 2000; 160:2193-8.

Hormones (Female)

Harman SM. Estrogen replacement in menopausal women: Recent and current prospective studies, the WHI and the KEEPS. Gend Med. 3:254-269 (2006).

Manson JE, Bassuk SS, Harman SM, Brinton EA, Cedars MI, Lobo R, Merriam GR, Miller VM, Naftolin F, and Santoro N. Postmenopausal hormone therapy: new questions and the case for new clinical trials. Menopause 2006 Jan-Feb;13(1):139-47.

Harman SM, Brinton EA, Cedars M, Lobo R, Manson JE, Merriam GR, Miller VM, Naftolin F, Santoro N. KEEPS: The Kronos Early Estrogen Prevention Study. Climacteric 2005 Mar;8(1):3-12.

Harman SM, Brinton EA, Clarkson T, Heward CB, Hecht HS, Karas RH, Judelson DR, Naftolin F. Is the WHI relevant to HRT started in the perimenopause? Endocrine 2004 Aug;24(3):195-202.

Naftolin F, Taylor HS, Karas R, Brinton E, Newman I, Clarkson TB, Mendelsohn M, Lobo RA, Judelson DR, Nachtigall LE, Heward CB, Hecht H, Jaff MR, and Harman SM; Women's Health Initiative. The Women's Health Initiative could not have detected cardioprotective effects of starting hormone therapy during the menopausal transition. Fertil Steril 2004 Jun;81(6):1498-501.

Oxidative Stress

Davies S, Traustadóttir T, Stock AA, Harman SM, Roberts, LJ. Mild forearm ischemia-reperfusion produces prolonged oxidative stress in older but not young subjects. (in preparation)

Harman SM, Liang L, Heward CB, Reaven P, Ping W, Cutler RL, and Duke R. Comparisons of Urinary Excretion of Three DNA Oxidation Adducts and Isoprostane F2a Measured by Liquid Choromatography-Mass Spectrometry in Smokers, Ex-smokers, and Non-smokers. Free Radic Biol Med 2003 Nov 15;35(10):1301-9.

Liang Y, Wei P, Duke R, Reaven P, Harman SM, Cutler RG, and Heward CB. Quantification of 8-iso-Prostaglandin-F2 and 2,3-dinor-8-iso-Prostaglandin-F2 in Human Urine using Liquid Chromatography-Tandem Mass Spectrometry. Free Radic Biol Med. 2003 Feb 15;34(4):409-18.

Cetinkaya A, Bulbuloglu E, Kantarceken B, Ciralik H, Belge Kurutas E, Buyukbese MA, Gumusalan Y. Effects of L-carnitine on oxidant/antioxidant status in acetic acid-induced colitis. Digestive Diseases and Sciences 2006; 51: 488-494.

Nutrition

Tsitouras, PD, Gucciardo F, Salbe, AD, Heward CB, and Harman SM. High omega-3 fat intake improves insulin sensitivity and reduces CRP and IL6, but does not affect other endocrine axes in healthy older adults. Horm Metab Res. 2008 Mar;40(3):199-205.

Le NTDS, Pannacciulli N, Chen K, Salbe AD, Hill JO, Wing RR, Reiman EM, Krakoff J. Confirmation of less activation in the left dorsolateral prefrontal cortex in response to a meal in obese versus lean women and association with successful weight loss. Am J Clin Nutr 2007; 86: 573-579.

Pannacciulli N, Salbe AD, Ortega E, Venti CA, Bogardus C, Krakoff J. Carbohydrate oxidation is a positive, independent predictor of ad-libitum food intake in humans. Am J Clin Nutr 2007; 86 625-632.

Pannacciulli N, Ortega E, Koska J, Salbe AD, Bunt JC, Krakoff J. Glucose response to an oral glucose tolerance test predicts weight change in non-diabetic subjects. Obesity Res 2007; 15: 632-639.

Pannacciulli N, Le DSNT, Salbe AD, Chen K, Reiman EM, Tataranni PA, Krakoff J. Postprandial glucagon-like peptide 1 (GLP-1) response is positively associated with changes in neuronal activity of brain areas implicated in satiety and food intake regulation in humans. NeuroImage 2007; 35: 511-517.

Salbe AD, Lindsay RS, Collins CB, Tataranni PA, Krakoff J, Bunt JC. Comparison of plasma insulin levels after a mixed meal challenge in children with and without intrauterine exposure to diabetes. J Clin Endocrinol Metab; 2007; 92: 624-628.

Swinburn BA, Jolley D, Kremer PJ, Salbe AD, Ravussin E. Estimating the effects of energy imbalance on changes in body weight in children. Am J Clin Nutr 2006; 83:859-863.

Le NTDS, Pannacciulli N, Chen K, DelParigi A, Salbe AD, Reiman EM, Krakoff J. Less activation of the left dorsolateral prefrontal cortex in response to a meal: a feature of obesity. Am J Clin Nutr 2006; 84:725-781.

DelParigi A, Chen K, Salbe AD, Hill JO, Wing RR, Reiman EM, Tataranni PA. Successful dieters have increased neural activity in cortical areas involved in the intentional control of behavior. Int J Obes (London) 2006.

Pannacciulli N, Bunt JC, Ortega E, Funahashi T, Salbe AD, Bogardus C, Krakoff J. Lower total fasting plasma adiponectin concentrations are associated with higher metabolic rates. J Clin Endocrinol Metab 2006; 91: 1600-1603.

Venti CA, Tataranni PA, Salbe AD. Lack of relationship between calcium intake and body size in an obesity-prone population. J Am Dietetic Assoc 2005; 105:1401-1407.

DelParigi A, Chen K, Salbe AD, Reiman EM, Tataranni PA. Sensory experience of food and obesity: a positron emission tomography study of the brain regions affected by tasting a liquid meal after a prolonged fast. NeuroImage 2005; 24:436-443.

Salbe AD, Tschoep MH, DelParigi A, Venti CA, Tataranni PA. Negative relationship between fasting plasma ghrelin concentration and ad libitum food intake. J Clin Endocinol Metab 2004; 89:2951-2956.

DelParigi A, Chen K, Salbe AD, Hill JO, Wing RR, Reiman EM, Tataranni PA. Persistence of abnormal neuronal response to a meal in post-obese individuals. Int J Obes Relat Metab Disorders 2004; 28:370-377.

Salbe AD, DelParigi A, Pratley RE, Drewnowski A, Tataranni PA. Taste preferences and body weight changes in an obesity-prone population. Am J Clin Nutr, 2004; 79:372-378.

DelParigi A, Chen K, Salbe AD, Reiman, E, Tataranni PA. Are we addicted to food? Obesity Res 2003; 11:493-495.

DelParigi A, Tschoep M, Heiman ML, Salbe AD, Vozarova B, Sell A, Bunt JC, Tataranni PA. High circulating ghrelin: a potential cause for hyperphagia and obesity in Prader-Willi syndrome. J Clin Endocrinol Metab 2002; 87:5461-5464.

DelParigi A, Chen K, Salbe AD, Gautier J-F, Ravussin E, Reiman EM, Tataranni PA. Tasting a liquid meal after a prolonged fast is associated with preferential activation of the left hemisphere. Neuroreport 2002; 13:1141-1145.

DelParigi A, Gautier J-F, Chen K, Salbe AD, Ravussin E, Reiman EM, Tataranni PA. Neuroimaging and Obesity. Mapping the brain responses to hunger and satiation in humans using positron emission tomography. Ann NY Acad Sci 2002; 967: 389-397.

DelParigi A, Gautier J-F, Chen K, Salbe AD, Pratley RE, Reiman EM, Tataranni PA. Sex differences in the human brain's response to hunger and satiation. Am J Clin Nutr 2002; 75:157-162.

Lindsay RS, Tataranni PA, Salbe AD, Hanson RL, Cook V, Knowler WC. Early excess weight gain of children in the Pima Indian population. Pediatrics 2002; 109.

Gautier J-F, DelParigi A, Chen K, Salbe AD, Pratley RE, Reiman EM, Tataranni PA. Effect of satiation on brain activity in obese and lean women. Obesity Res 2001; 9:676-684.

Pratley RE, Baier LJ, Pan DA, Salbe AD, Storlien L, Ravussin E, Bogardus C. Effects of an Ala54Thr polymorphism in the intestinal fatty acid biding protein on responses to dietary fat in humans. J Lipid Res 2000; 41:2002-2008.

Gautier J-F, Chen K, Salbe AD, Bandy D, Pratley RE, Heiman, E, Ravussin E, Reiman EM, Tataranni PA. Differential brain responses to satiation in obese and lean men. Diabetes 2000; 49:838-846.

Weyer C, Pratley RE, Salbe AD, Bogardus C, Ravussin E, Tataranni PA. Energy expenditure, fat oxidation and body weight regulation: a study of metabolic adaptation to long-term weight change. J Clin Endo Metab 2000; 85:1087-1094.

Guven A, Cetinkaya A, Aral M, Sokmen G, Buyukbese MA, Guven A, Koksal N. High sensitivity C-reactive protein in patients with metabolic syndrome Angiology 2006; 57: 295-302.

Exercise

Traustadóttir T, Stock AA, Harman SM. High-dose statin treatment does not impair aerobic capacity or muscle function in older adults. A pilot study. (in review)

Marcell TJ, McAuley KA, Traustadóttir T, Reaven PD. Exercise training is not associated with improved levels of C-reactive protein or adiponectin. Metabolism 2005, 54(4):533-541.

Franks PW, Ravussin E, Hanson RL, Harper IT, Allison, DB, Knowler WC, Tataranni PA, Salbe AD. Habitual physical activity in children: The role of genes and the environment. Am J Clin Nutr 2005; 82:901-908.

Traustadóttir T, Bosch PR, Matt KS. The HPA axis response to stress in women: Effects of aging and fitness. Psychoneuroendocrinology 2005, 30(4):392-402.

Traustadóttir T, Bosch PR, Cantu T, Matt KS. Hypothalamic-Pituitary-Adrenal axis response and recovery from high intensity exercise in women: Effects of aging and fitness. J Clin Endocrin Metab 2004, 89(7):3248-3254.

Salbe AD, Weyer C, Harper I, Lindsay RS, Ravussin E, Tataranni PA. Relation between physical activity and obesity. Letter to the Editor, Am J Clin Nutr, 2003; 78:190-195.

Salbe AD, Weyer C, Harper I, Lindsay RS, Ravussin E, Tataranni PA. Assessing risk factors for obesity between childhood and adolescence: II. Energy metabolism and physical activity. Pediatrics 2002; 110:307-314.

Etnier JL, Romero DH, Traustadóttir T. Acquisition and retention of motor skills as a function of age and aerobic fitness. J of Aging and Phys Activity 2001, 9(4):425- 437.

Traustadóttir T, Bosch P, Matt KS. (2002). Neuroendocrine stress responses: Survival of the fittest. Stress, 5:114.

Traustadóttir T, Bosch PR, Matt KS. (2002). Cognitive performance and stress in fit and unfit older adults. Med Sci Sport Ex, 34(5):S71.

Traustadóttir T, Etnier JL, Romero DH. (2000). Predicting maximal oxygen consumption in healthy, older adults, using a modified 800m walk test. Med Sci Sport Ex, 32:S317.

Diabetes and Obesity

Brillon DJ, Sison C, Salbe AD, Poretsky L. Reproducibility of a glycemic response to mixed meals in type 2 diabetes mellitus. Hormone Metab Res 2006; 38:536-542.

Bunt JC, Tataranni PA, Salbe AD. Intrauterine exposure to diabetes is a determinant of hemoglobin A1C and systolic blood pressure in Pima Indian children. J Clin Endocrinol Metab 2005; 90:3225-3229.

Bunt JC, Salbe AD, Harper IT, Hanson RL, Tataranni PA. Weight, adiposity and physical activity as determinants of insulin sensitivity in Pima Indian children. Diabetes Care 2003; 26:2524-2530.

Ortega E, Koska J, Salbe AD, Tataranni PA, Bunt J. Serum gamma-glutamyl transpeptidase (GGT) is a determinant of insulin resistance (HOMA-IR) independent of adiposity in Pima Indian children. J Clin Endocrinol Metab 2006; 91:1419-1422.

Stefan N, Bunt JC, Salbe AD, Funahashi T. Matsuzawa Y, Tataranni PA. Plasma adiponectin concentrations in children: relationships with obesity and insulinemia. J Clin Endocrinol Metab 2002; 87:4652-4656.

Weyer C, Salbe AD, Lindsay RS, Pratley RE, Bogardus C, Tataranni PA. Exaggerated pancreatic polypeptide secretion in Pima Indians: Can an increased parasympathetic drive to the pancreas contribute to hyperinsulinemia, obesity, and diabetes in humans? Metabolism 2001; 50:223-230.

Kantarceken B, Cetinkaya A, Inanc Tolun F, Yerhan H, Citirik C, Buyukbese MA: Metabolic conditions of fatty liver in non-diabetic obese women. J Endocrinol Invest. 2007; 30(8): 672-676.

Cetinus E, Buyukbese MA, Uzel M, Ekerbicer H, Karaoguz A. Hand Grip Strength in patients with type 2 diabetes mellitus. Diabetes Research and Clinical Practice 2005; 70: 278-286.

Dogan E, Erkoc R, Sayarlioglu H, Buyukbese A. Nonketotic hyperosmolar coma in a patient with type 1 diabetes-related nephropathy: case report. Advances in Therapy 2005; 22: 429-432.

Gul M, Kurutas E, Ciragil P, Cetinkaya A, Kilinc M, Aral M, Buyukbese MA. Urinary tract infection aggravates oxidative stress in diabetic patients. The Tohoku Journal of Experimental Medicine 2005; 206: 1-6.

Buyukbese MA, Cetinkaya A, Kocabas R, Guven A, Tarakcioglu M: Leptin levels in obese women with and without type 2 diabetes mellitus. Mediators of Inflammmation 2004;13: 321-325.

Ozdemir M, Buyukbese MA, Cetinkaya A, Ozdemir G. The risk factors for the ocular surface disorders and tear dysfunction in non-insulin dependent diabetes mellitus. Diabetes Research and Clinical Practice 2003; 59:195-199.

Other

Reaven PD, Traustadóttir T, Brennan, J, Nader, PR. Cardiovascular risk factors associated with insulin resistance in children persist into late adolescence. Diabetes Care 2005, 28(1):148-150.

Traustadóttir T, Bosch PR, Matt KS. Gender differences in cardiovascular and hypothalamic-pituitary-adrenal axis responses to psychological stress in healthy older adult men and women. Stress 2003, 6(2):133-140.

Matt KS, Traustadóttir T, Bosch P, Cantu T. (2002). A neuroendocrine model of stress. The balance between the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis. Stress, 5:112.

Traustadóttir T, Bosch PR, Matt KS. (2001). Neuroendocrine stress responses: Effect of gender. Hormones and Behavior, 39:352.

Harman SM, Gucciardo F, Heward CB, Granstrom P, Barkley-White B, Rogers LW, and Ibarra JA, Jr. Discrimination of breast cancer by anti-malignin antibody serum test in women undergoing biopsy. Cancer Epidemiol Biomarkers Prev 2005 Oct;14(10):2310-5.

Hecht HS and Harman SM. Comparison of the effects of atorvastatin versus simvastatin on subclinical atherosclerosis in primary prevention, as determined by electron beam tomography. Am J Cardiol 2003 Jan 1;91(1):42-5.

Harman SM. The Kronos Longevity Research Institute. Exp Gerontol 2003 May;38(5):483-7.

Kokoglu OF, Ucmak H, Hosoglu S, Cetinkaya A, Kantarceken B, Buyukbese MA, Isik IO. Efficacy and tolerability of pegylated-interferon alpha-2a in hemodialysis patients with chronic C hepatitis. Journal of Gastroenterology and Hepatology 2006; 21: 575-580.

Kokoglu OF, Hosoglu S, Geyik MF, Ayaz C, Akal?n S, Buyukbese MA, Cetinkaya A. Clinical and laboratory features of brucellosis in two university hospitals in southeast Turkey. Tropical Doctor 2006; 36:49-51.

Buyukbese MA, Cetinus A, Cetinkaya A, Aras S. Ferritin level in postmenopausal women does not seem to play a significant role on osteoporosis. Southern Medical Journal 2005; 98: 845.

Cetinkaya A, Bulbuloglu E, Belge Kurutas E, Ciralik H, Kantarceken B, Buyukbese MA. Beneficial effects of N-acetylcysteine on acetic acid-induced colitis in rats. The Tohoku Journal of Experimental Medicine 2005; 206:131-139.

Cetinkaya A, Belge Kurutas E, Buyukbese MA, Kantarceken B, Bulbuloglu E. Levels of malondialdehyde and superoxide dismutase in subclinical hyperthyroidism. Mediators of Inflammation 2005; 1: 57-59.

Bakaris S, Ozdemir M, Isik IO, Buyukbese MA, Ozdemir G: Impression cytology changes and corneoconjunctival calcification in patients with chronic renal failure. Acta Cytologica (The Journal of Clinical Cytology and Cytopathology) 2005; 49: 1-6.

Buyukbese MA, Koksal N, Guven A, Cetinkaya A: The effects of "Maras powder" use on respiratory functions. The Tohoku Journal of Experimental Medicine 2004; 204: 173-178.

Ozdemir M, Bakaris S, Ozdemir G, Buyukbese MA, Cetinkaya A. Ocular surface disorders and tear function changes in patients with chronic renal failure. Canadian Journal of Ophthalmology 2004; 39: 526-532.

Ozdemir S, Buyukbese MA, Kadioglu P, Soysal T, Senturk H, Akin P: Plasmapheresis: An effective therapy for refractory hyperthyroidism in the elderly. Indian Journal of Medical Sciences 2002; 56: 65-68.

Koksal N, Buyukbese MA, Guven A, Cetinkaya A, Hasanoglu HC. Organophosphate intoxication as a consequence of mouth to mouth breathing from an affected case. Chest 2002; 122:740-741.

Altinli E, Pekmezci S, Balkan T, Somay A, Buyukbese MA, Tasci H, Akcal T. Castleman's disease masquerading as sigmoid colon tumor and Hodgkin lymphoma; a report of two cases. Swiss Surgery 2002; 8: 7-10.