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Pilot Study of the Effects of Vinegar on Glucose Absorption

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A Pilot Study of the Effects of Vinegar on Glucose Absorption: The Vinegar Pilot Study is a randomized, placebo-controlled study on the effects of common household vinegar on glucose absorption in healthy volunteers aged 20-85 years. In both animal and human studies, vinegar appears to have potent glucose-lowering effects. However, the mechanism of action remains in question and understanding the way vinegar lowers blood sugar is critical to making effective recommendations for its use. We propose to assess the effects of vinegar on glucose absorption by using the oral octreotide/insulin suppression test. This test is designed to quantify the glucose rate absorption from the digestive tract and differs from the established intravenous method in that the duration is shorter; the glucose is administered orally; and the insulin infusion rate will be lower. Each participant will have four study visits, each lasting approximately 4 hours, at one-week intervals. Glucose and insulin will be measured in blood samples taken every 20 minutes for 180 minutes after a carbohydrate meal. The rate of glucose rise will be calculated as an index of standardized glucose absorption, allowing us to determine whether the vinegar ingestion slows glucose uptake from the intestine.

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